Searchable abstracts of presentations at key conferences in endocrinology

ea0026p509 | Bone/calcium/Vitamin D | ECE2011

DT56a (Femarelle), contrary to estradiol-17β, has a positive stimulatory effect on human derived female cultured bone cells in hyperglycemic conditions

Somjen D , Katzburg S , Sharon O , Hendel D , Yoles I

We have previously reported, that cultured female- derived human Osteoblats (hObs) responded to DT56a (Femarelle). Since the skeletal protective effects of estrogens are not discernible in diabetic women, we sought to test the effects of DT56a on hObs grown in high glucose concentration in the growth medium (HG) as compared to estradiol-17β (E2). We used the stimulation of creatine kinase specific activity (CK), and 3[H] thymidine incorporation into ...